Girls Frozen Socks - Pack of 2

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Although clinical exams for neuropathy and total neuropathy scores were performed, comparisons between intervention and control side not included in evaluation Christodoulou C., Tsakalos G., Galani E., & Skarlos D. V. (2006). Scalp metastases and scalp cooling for chemotherapy-induced alopecia prevention. Annals of Oncology, 17( 2), 350 Small sample size with high dropout rate (29 down to 7) in part due to discomfort with intervention Occurrence of Patient Neurotoxicity Questionnaire grades D or E peripheral neuropathy reduced with intervention (hand: 2.8% vs. 41.7%, p< .001; foot: 2.8 vs. 36.1%, p< .001)

The Impact of Peripheral Cooling on Chemotherapy-Induced

Bhatnagar B., Gilmore S., Goloubeva O., Pelser C., Medeiros M., Chumsri S.,...Bao T. (2014). Chemotherapy dose reduction due to chemotherapy induced peripheral neuropathy in breast cancer patients receiving chemotherapy in the neoadjuvant or adjuvant settings: A single-center experience. SpringerPlus, 3, Article number: 366. 10.1186/2193-1801-3-366 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar] Shah A., Hoffman E. M., Mauermann M. L., Loprinzi C. L., Windebank A. J., Klein C. J., & Staff N. P. (2018). Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. Journal of Neurology, Neurosurgery, and Psychiatry, 89( 6), 636–641. 10.1136/jnnp-2017-317215 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Hershman D. L., Lacchetti C., & Loprinzi C. L. (2014). Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary. Journal of Oncology Practice, 10( 6), e421–e424. 10.1200/JOP.2014.001776 [ PubMed] [ CrossRef] [ Google Scholar] National Cancer Institute’s Common Toxicity Criteria, version 2.0, translated into Danish, including sensory neuropathy symptomsMarks D. H., Qureshi A., & Friedman A. (2018). Evaluation of prevention interventions for taxane-induced dermatologic adverse events: A systematic review. JAMA Dermatology, 154( 12), 1465–1472. 10.1001/jamadermatol.2018.3465 [ PubMed] [ CrossRef] [ Google Scholar] No significant difference in Neuropathic Pain Symptom Inventory scores for symptoms in hands ( p> .15) or feet ( p> .30); no significant difference in quantitative sensory testing results ( p> .15); and pain severity using the Brief Pain Inventory was increased for all measures across time

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Komen M. M., Smorenburg C. H., van den Hurk C. J., & Nortier J. W. (2013). Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. Oncologist, 18( 7), 885–891. https://dx.doi.org/10.1634%2Ftheoncologist.2012-0332 [ PMC free article] [ PubMed] [ Google Scholar] Similar benefit after subsequent chemo cycles (odds ratio: 0.59; 95% CI = 0.46–0.76, p< .0001), although analysis of impact of preexisting peripheral neuropathy not performed in statistics for late peripheral neuropathy group Sato J., Mori M., Nihei S., Kumagai M., Takeuchi S., Kashiwaba M., & Kudo K. (2016). The effectiveness of regional cooling for paclitaxel-induced peripheral neuropathy. Journal of Pharmaceutical Health Care and Sciences, 2, Article number: 33 Tsuyuki S., Senda N., Kanng Y., Yamaguchi A., Yoshibayashi H., Kikawa Y.,...Inamoto T. (2016). Evaluation of the effect of compression therapy using surgical gloves on nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A phase II multicenter study by the Kamigata Breast Cancer Study Group. Breast Cancer Research in Treatment, 160( 1), 61–67. 10.1007/s10549-016-3977-7 [ PubMed] [ CrossRef] [ Google Scholar]

Sundar R., Bandla A., Tan S. S., Liao L. D., Kumarakulasinghe N. B., Jeyasekharan A. D.,...Wilder-Smith E. P. (2016). Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study. Frontiers in Oncology, 6, 274 Griffiths C., Kwon N., Beaumont J. L., & Paice J. A. (2018). Cold therapy to prevent paclitaxel-induced peripheral neuropathy. Supportive Care in Cancer, 26( 10), 3461–3469. 10.1007/s00520-018-4199-9 [ PubMed] [ CrossRef] [ Google Scholar]

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Correlation between motor nerve amplitude preservation at 6 months and degree of skin cooling achieved, which demonstrated statistical significance ( p< .0005) No statistically significant preservation of hand or foot cold sense, vibration perception, electrophysiological measurements Bandla A., Sundar R., Liao L. D., Sze Hui Tan S., Lee S. C., Thakor N. V., & Wilder-Smith E. P. (2016). Hypothermia for preventing chemotherapy-induced neuropathy - a pilot study on safety and tolerability in healthy controls. Acta Oncologica, 55( 4), 430–436. 10.3109/0284186X.2015.1075664 [ PubMed] [ CrossRef] [ Google Scholar] Evaluate efficacy of compression with surgical gloves to prevent nanoparticle albumin-bound paclitaxel-associated peripheral neuropathy Scotte F., Tourani J. M., Banu E., Peyromaure M., Levy E., Marsan S.,...Oudard S. (2005). Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. Journal of Clinical Oncology, 23( 19), 4424–4429. 10.1200/JCO.2005.15.651 [ PubMed] [ CrossRef] [ Google Scholar]Mols F., Beijers T., Vreugdenhil G., & van de Poll-Franse L. (2014). Chemotherapy-induced peripheral neuropathy and its association with quality of life: A systematic review. Supportive Care in Cancer, 22( 8), 2261–2269. 10.1007/s00520-014-2255-7 [ PubMed] [ CrossRef] [ Google Scholar] de Lemos M. L., & Walisser S. (2005). Management of extravasation of oxaliplatin. Journal of Oncology Pharmacy Practice, 11( 4), 159–162. 10.1191/1078155205jp165oa [ PubMed] [ CrossRef] [ Google Scholar] The single study in this review that achieved fingertip cooling by compression with surgical gloves demonstrated statistically significant benefits with the intervention ( Tsuyuki et al., 2016). It should be noted that it is uncertain to what degree the observed benefit in this study is attributed to a decrease in circulation at target tissues compared with a resulting decrease in temperature. Additional studies are needed to further assess the validity of the findings in the Tsuyuki study and to discern benefit from compression compared with direct cooling. Fingertip cooling by compression offers a promising area for further study given its low cost, ease of application, and seemingly good tolerability. Patient Neurotoxicity Questionnaire results: significantly lower grades of peripheral neuropathy in the intervention side ( p< .0001) Compound motor action potential amplitudes of motor nerves more preserved at 3 months post treatment. Did not achieve statistical significance. Extensor digitorum brevis compound motor action potential amplitudes more preserved on intervention side below fibula head ( p = .07) and above fibula head ( p = .10).

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Tofthagen C., Overcash J., & Kip K. (2012). Falls in persons with chemotherapy-induced peripheral neuropathy. Supportive Care in Cancer, 20( 3), 583–589. 10.1007/s00520-011-1127-7 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]Tofthagen C. (2010). Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing, 14( 3), E22–E28. 10.1188/10.CJON.E22-E28 [ PubMed] [ CrossRef] [ Google Scholar]